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NEW QUESTION: 1
Gene therapy offers a new treatment paradigm for curing human disease. Rather than altering the disease phenotype by using agents that interact with gene products, or are themselves gene products, gene therapy can theoretically modify specific genes resulting in disease cure following a single administration.
Initially gene therapy was envisioned for the treatment of genetic disorders, but is currently being studied for use with a wide range of diseases, including cancer, peripheral vascular disease, arthritis, Neurodegenerative disorders and other acquired diseases.
Certain key elements are required for a successful gene therapy strategy. The most elementary of these is that the relevant gene be identified and cloned. Upon completion of the Human Genome Project, gene availability will be unlimited. Once identified and cloned, the next consideration must be expression of the gene. Questions pertaining to the efficiency of gene transfer and gene expression remain at the forefront of gene therapy research, with current debates revolving around the transfer of desired genes to appropriate cells, and then to obtaining sufficient levels of expression for disease treatment. With luck, future research on gene transfer and tissue-specific gene expression will resolve these issues for the majority of gene therapy protocols.
Other important considerations for a gene therapy strategy include a sufficient understanding of the pathogenesis of the targeted disorder, potential side effects of the gene therapy treatment, and a more in depth understanding of the target cells which are to receive gene therapy.
Gene transfer vector is the mechanism by which the gene is transferred into a cell. Currently there are at least 150 clinical gene therapy protocols worldwide. Since the approval process for these protocols is not as public outside the U.S., it is difficult to ascertain the exact number of worldwide protocols. As of December 1995, 1024 patients had been treated with either a gene transfer or gene therapy protocol.
Much controversy exists regarding how many of these patients have benefited from their gene therapy, and no one has yet been cured.
Public controversy in the field of human gene therapy is driven by several factors. Ordinary citizens as well as scientists easily understand the enormous potential of gene therapy, but the former may not appreciate all the pitfalls and uncertainly that lie in the immediate future. The financial interests of biotechnology firms and, some have asserted the career interests of some gene therapists have encouraged extravagant, or at least verily optimistic public statements about contemporary gene therapy. In spite of the proliferation of protocols, the actual number of patients treated remains small, and only one genuinely controlled study of human gene therapy has been published as of this date All of the following are mentioned in the passage as elements that are required for a successful gene therapy strategy EXCEPT:
A. Expressing the relevant gene
B. Gaining and a more in depth understanding of the target cells which are to receive gene therapy.
C. Identifying the relevant gene
D. Determining the side effects of the relevant gene
E. Understanding of the pathogenesis of the targeted disorder
Answer: D
Explanation:
Explanation/Reference:
Explanation:
The best answer is C.
One must determine the side effects of the relevant gene therapy treatment, and not of the relevant gene itself

NEW QUESTION: 2
A Solutions Architect must review an application deployed on EC2 instances that currently stores multiple
5-GB files on attached instance store volumes. The company recently experienced a significant data loss after stopping and starting their instances and wants to prevent the data loss from happening again. The solution should minimize performance impact and the number of code changes required.
What should the Solutions Architect recommend?
A. Store the application data in Amazon DynamoDB
B. Store the application data in Amazon ElastiCache
C. Store the application data in Amazon S3
D. Store the application data in an EBS volume
Answer: D

NEW QUESTION: 3
When IP Source Guard with source IP filtering is enabled on an interface, which feature must be enabled on the access VLAN for that interface?
A. spanning-tree portfast
B. private VLAN
C. DHCP snooping
D. storm control
Answer: C
Explanation:
Explanation/Reference:
Explanation:
IP Source Guard Configuration Guidelines
You can configure static IP bindings only on nonrouted ports. If you enter the ip source binding mac- address vlan vlan-id ip-address interface interface-id global configuration command on a routed interface, this error message appears:
Static IP source binding can only be configured on switch port. When IP source guard with source IP filtering is enabled on an interface, DHCP snooping must be enabled on the access VLAN for that interface. If you are enabling IP source guard on a trunk interface with multiple VLANs and DHCP snooping is enabled on all the VLANs, the source IP address filter is applied on all the VLANs. You can enable this feature when 802.1x port-based authentication is enabled.
Reference: http://www.cisco.com/c/en/us/td/docs/switches/lan/catalyst2960x/software/15- 0_2_EX/ security/configuration_guide/b_sec_152ex_2960-x_cg/b_sec_152ex_2960- x_cg_chapter_01110.html